Eight Saints Up The Anti Night Cream review for menopausal skin

The answer in one table

What the official ingredient list shows

The official product page, checked October 10, 2026, lists deionized water, aloe leaf juice, safflower oil, glycerin, glyceryl stearate, stearic acid, sunflower seed oil, isopropyl palmitate, jojoba oil, vitamin E, shea butter and vitamin B5 near the top. Later come niacinamide, botanical hyaluronic acid, amino acids and several palmitoyl peptides, green tea, gotu kola, horsetail, wild geranium and dandelion extracts, xanthan gum and polysorbate 20.

What that means for a buyer:

• Moisture base: glycerin, plant oils, shea butter and stearic acid make it a conventional emollient cream, not a lightweight gel.
• Niacinamide and peptides: both are present, but no percentage is published. Their position in the list does not tell you whether they are present at a level that changes skin.
• Lactic acid: it is listed in the middle of the formula. Lactic acid can work as an exfoliant, but in a cream it may also be there to adjust pH, and the page does not say which. It is not a strong acid product on this evidence.
• No retinoid and no fragrance line: the list has neither retinol nor a “fragrance/parfum” entry. The description does promise a “natural green tea scent,” so do not treat it as fragrance-free.
• Isopropyl palmitate: an emollient some breakout-prone readers prefer to avoid.

Ingredient databases sometimes describe this product differently, including as containing AHA ingredients. Where they disagree, the official list and your own package are the authority. Formulas and regional versions can change.

Is Up The Anti a good night cream for mature skin?

It may suit you if:

• you want a night cream with niacinamide and peptides, not just a plain barrier cream;
• your skin is dry but not currently itchy, burning or red;
• you do not mind a scent and have used botanical creams before without trouble.

Skip it, or ask a clinician first, if:

• your skin is newly sensitive, stinging, or you are trying to calm itch. Start with the steps in menopausal skin suddenly sensitive and fragrance-free versus unscented;
• you react to fragrance or plant extracts;
• you are breakout-prone and want the simplest formula. See moisturizers for dry, breakout-prone skin.

Persistent dryness, itch or rash is a reason to see a qualified clinician. A cosmetic cream does not diagnose or treat a skin condition.

What the evidence says

The brand’s study summary page describes a 28-day consumer perception study with 33 healthy female participants, run in late 2022. They used All In Eye Cream twice daily and Up The Anti once each evening, and answered a questionnaire. The page reports results as “4 out of 5” or “5 out of 5” agreeing statements such as feeling more hydrated.

That is useful, but limited. There was no comparison group, the two products were used together, results are self-reported, and participants are not described by age or menopause status. It is not evidence that the cream works better than a basic moisturizer, and it says nothing specific about menopausal skin.

Product-page phrases such as “reversing signs of aging” and “clinically proven” go further than a consumer perception study can support. We do not repeat them. The Amazon listing also shows a large number of ratings; a high count shows popularity, not better results.

Pros and cons

Pros

• Niacinamide, peptides and hyaluronic acid in a cream base.
• The list shows no retinoid, so it is less likely to behave like a retinol product.
• Moderate price, especially at Amazon’s current listing.
• The brand publishes its full ingredient list and a 30-day money-back guarantee on its own site.

Cons

• Not designed for or tested on menopausal skin.
• Scented, with several botanical extracts.
• Active concentrations are not published.
• Study evidence is a small, uncontrolled consumer questionnaire.

Comparison: Up The Anti or Caire Triple Lift Molecule Mask?

These are different product types, so this is a “which purchase fits” comparison, not a ranking.

How to choose: if you want one daily product, the night cream is the more practical purchase. The mask is an optional extra, and per-ounce price is not a fair comparison because you use a mask far less often. Neither is established as better for menopausal skin. A plain moisturizer from our best moisturizers for menopausal dry skin list may serve you as well at lower cost.

Quick comparison: night cream or mask

This comparison is researched from official pages, not tested. Prices and ratings change; check dates are shown.

Eight Saints Up The Anti Night Cream

About $34 on Amazon, checked October 10, 2026 (2 oz). Brand site: $44.

Key ingredients

Glycerin, plant oils, shea butter, niacinamide, peptides, lactic acid; no retinoid.

Best for

A daily night moisturizer with niacinamide and peptides, if a scent is acceptable.

Watch out for

Scented, with botanical extracts; not made for menopause; study is a small consumer survey.

Caire Triple Lift Molecule Mask

About $64 on Amazon, checked October 10, 2026 (40 ml / 1.35 fl oz).

Key ingredients

Pullulan, hyaluronate ingredients, glycerin, betaine, botanical extracts.

Best for

An optional weekly mask ritual; see our Caire review.

Watch out for

Extra time and cost; firmness claims are brand-reported.

Different jobs, so this is a purchase-fit comparison. Neither is established as better for menopausal skin.

Price check

Prices change, and sizes differ between sellers. Confirm the selected size and seller before ordering.

Where it fits in a routine

Use it in the evening after cleansing. Introduce it on its own, patch test on the inside of your arm for a few days and give it a couple of weeks before judging, as with any new product. Pair it with sunscreen in the morning; our simple menopause skincare routine shows the basic order. For a night-cream decision in general, see does menopausal dry skin need a separate night cream.

Eight Saints also sells a Firm Intentions Neck Cream with a similar-looking ingredient list. The official page describes it as unscented and for the neck and décolleté. We have not compared the two formulas line by line; if you already use Up The Anti, check whether you need a second jar. Our Firm Intentions review covers it. The same brand’s All In Eye Cream and Night Shift Hydration Gel are reviewed separately. Another menopause-labelled night cream is No7 Nourishing Overnight Cream.

Questions before buying

Is Eight Saints Up The Anti worth it?

It is worth considering as a moderately priced night cream if you want niacinamide and peptides and are comfortable with a scent. It is not worth paying extra for on the promise of reversing aging, which the evidence does not support.

Is Up The Anti good for menopausal or mature skin?

It is marketed to all skin types, not to menopause. It has a rich emollient base that could suit dry mature skin, but reactive skin may prefer a simpler, fragrance-free cream.

Does Up The Anti contain retinol or AHA?

The official list has no retinol or retinoid. It does include lactic acid, an AHA, but the concentration is not stated and it is listed well down the formula. The FDA notes that AHA ingredients can increase sun sensitivity, so daily sunscreen matters with any AHA product. If you use it with a stronger exfoliant or retinoid product, introduce changes one at a time and read the retinol irritation guide.

Can I use it every night?

The directions say to massage it onto clean skin before bed and use daily. Start every second night if your skin is sensitive, and stop if it stings or becomes red.

Is Up The Anti safe around the eyes?

The brand sells a separate eye cream. Check the directions on your own package before using any face cream near the eyes.

The researched verdict

Up The Anti is a decent, scented night moisturizer with niacinamide and peptides at a fair price, and it is not a menopause treatment. Buy it because you like the texture and ingredients, patch test first, and keep expectations modest. If your priority is calming dry, itchy or reactive skin, begin with a simpler product.

Manufacturer ingredient list, directions, study summary and price checked October 10, 2026. Read your package’s current ingredient list before use.

• Eight Saints All In Eye Cream review
• Caire Beauty review
• Best moisturizers for menopausal dry skin
• FDA, alpha hydroxy acids